The Orange Family was mentioned in The Cutie Mark Chronicles, where the Orange Family was mentioned in Applejack's story. Applejack goes travels away from Sweet Apple Acres to find a new life and future, so she decides to go to her relatvies, the Orange Family.
Aunt Orange then welcomes Applejack to the family, and teaches her how to be polite. Later on when Applejack goes to her room, she sees Rainbow Dash's sonic rainboom and decides to run home to Apple Acres.
The Orange Family has only been mentioned once throughout the whole My Little Pony: Friendship is Magic series and is unkown if they will be mentioned again.